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Article

TCR independent suppression of CD8(+) T cell cytokine production mediated by IFNγ in vivo.

Virology - 1 Nov 2016

Hosking Martin P, Flynn Claudia T, Whitton J Lindsay

Abstract excerpt

CD8(+) memory T cells produce IFNγ within hours of secondary infection, but this is quickly terminated in vivo despite the presence of stimulatory viral antigen, suggesting that active suppression occurs. Herein, we investigated the in vivo effector function of CD8(+) memory T cells during successive encounters with viral antigen. CD8(+) T cells in immune mice receiving prior viral or peptide challenge failed to...

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Identifiers

PMID: 27564543
DOI: 10.1016/j.virol.2016.08.003
PMCID: PMC5045820

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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