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Article

Cyclin-specific control of ribosomal DNA segregation.

Molecular and cellular biology - 1 Sept 2008

Sullivan Matt, Holt Liam, Morgan David O

Abstract excerpt

Following chromosome duplication in S phase of the cell cycle, the sister chromatids are linked by cohesin. At the onset of anaphase, separase cleaves cohesin and thereby initiates sister chromatid separation. Separase activation results from the destruction of its inhibitor, securin, which is triggered by a ubiquitin ligase called the anaphase-promoting complex (APC). Here, we show in budding yeast that securin...

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Share to Anaphase-Promoting Complex-Cyclosome
Share to Chromosome Segregation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Replication

Share to DNA, Ribosomal

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Source

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Identifiers

PMID: 18591250
DOI: 10.1128/MCB.00235-08
PMCID: PMC2519743

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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