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Article

Expression of CYP4A1 in U251 human glioma cell induces hyperproliferative phenotype in vitro and rapidly growing tumors in vivo.

The Journal of pharmacology and experimental therapeutics - 1 Oct 2008

Guo Austin M, Sheng Ju, Scicli Gloria M, Arbab Ali S, Lehman Norman L, Edwards Paul A, Falck John R, Roman Richard J, Scicli A Guillermo

Abstract excerpt

Exogenous 20-hydroxyeicosatetraenoic acid (20-HETE) increases the growth of human glioma cells in vitro. However, glioma cells in culture show negligible 20-HETE synthesis. We examined whether inducing the expression of a 20-HETE synthase in a human glioma U251 cell line would increase proliferation. U251 cells transfected with CYP4A1 cDNA (termed U251 O) increased the formation of 20-HETE from less than 1 to...

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Identifiers

PMID: 18591218
DOI: 10.1124/jpet.108.140889
PMCID: PMC2636507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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