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Suppression of CD44 expression decreases migration and invasion of human glioma cells

10 Apr 1996

Abstract excerpt

We have reported high expression of CD44H in human glioma cells. To investigate the role of CD44H in the invasion of human glioma, we established a CD44-anti-sense-gene-expression glioma cell line named U-251A1. The expression of CD44H in the G-418-selected U-251A1 cells was reduced to 20% of that in the parental U-251SP cells, as determined by flow-cytometry analysis. We first examined the migratory responses of...

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PMID: 8603821
DOI: 10.1002/(sici)1097-0215(19960410)66:2<255::aid-ijc20>3.0.co;2-a

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