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Article

Properties of an immortalised vascular endothelial/glioma cell co-culture model of the blood-brain barrier

1 Apr 1996

Abstract excerpt

In an effort to obtain a useful in vitro model possessing some of the properties of the blood-brain barrier, we have investigated the properties and interactions of immortalized cell lines. Immortalised human umbilical vein endothelial cells (HUVEC-304), in co-culture with rat C6 glioma cells in a two-chambered assembly, form tight junctional complexes, and develop a permeability barrier having a high...

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PMID: 8698844
DOI: 10.1002/(sici)1097-4652(199604)167:1<81::aid-jcp9>3.0.co;2-8

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