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Article

Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2006

Zhang Xue, Li Feng, Bulloj Ayelen, Zhang Yun-Wu, Tong Gang, Zhang Zhuohua, Liao Francesca-Fang, Xu Huaxi

Abstract excerpt

Neurofibrillary tangles (NFTs), consisting of abnormally hyperphosphorylated tau, are implicated in the pathogenesis of several neurodegenerative diseases including Alzheimer's disease (AD). The molecular mechanisms underlying the regulation of tau phosphorylation are largely unknown. While the P...

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Source

Identifiers

PMID: 16645045
DOI: 10.1096/fj.06-5721fje

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16645045-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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