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Article

Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2006

Zhang Xue, Li Feng, Bulloj Ayelen, Zhang Yun-Wu, Tong Gang, Zhang Zhuohua, Liao Francesca-Fang, Xu Huaxi

Abstract excerpt

Neurofibrillary tangles (NFTs), consisting of abnormally hyperphosphorylated tau, are implicated in the pathogenesis of several neurodegenerative diseases including Alzheimer's disease (AD). The molecular mechanisms underlying the regulation of tau phosphorylation are largely unknown. While the PI3K/Akt pathway has been shown to regulate multiple cellular events pertinent to AD pathogenesis, potential functions...

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PMID: 16645045
DOI: 10.1096/fj.06-5721fje

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PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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