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Transglutaminase 1 and its regulator tazarotene‐induced gene 3 localize to neuronal tau inclusions in tauopathies

18 Aug 2011

Abstract excerpt

Alzheimer's disease (AD), progressive supranuclear palsy (PSP), frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), and Pick's disease (PiD) are commonly known as tauopathies. Neurodegeneration observed in these diseases is linked to neuronal fibrillary hyperphosphorylated tau protein inclusions. Transglutaminases (TGs) are inducible enzymes, capable of modifying conformational and/or...

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PMID: 22009441
DOI: 10.1002/path.2984

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