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Article

Functional characterization of the microtubule-binding and -destabilizing domains of CPAP and d-SAS-4.

Experimental cell research - 15 Aug 2008

Hsu Wen-Bin, Hung Liang-Yi, Tang Chieh-Ju C, Su Chia-Li, Chang Yulin, Tang Tang K

Abstract excerpt

We previously identified a novel centrosomal protein CPAP, which carries a 112-residue motif that is essential for microtubule destabilization. In this report, we define both the microtubule (MT) binding and destabilizing domains in human CPAP and analyze the mutations that affect its MT-destabilizing activity. Analysis of a series of CPAP truncated proteins showed that the MT-binding domain (MBD; residues...

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Identifiers

PMID: 18586240
DOI: 10.1016/j.yexcr.2008.05.012

Genes

CPAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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