Article
Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length.
Nature communications - 16 Jun 2016
Zheng Xiangdong, Ramani Anand, Soni Komal, Gottardo Marco, Zheng Shuangping, Ming Gooi Li, Li Wenjing, Feng Shan, Mariappan Aruljothi, Wason Arpit, Widlund Per, Pozniakovsky Andrei, Poser Ina, Deng Haiteng, Ou Guangshuo, Riparbelli Maria, Giuliano Callaini, Hyman Anthony A, Sattler Michael, Gopalakrishnan Jay, Li Haitao
Abstract excerpt
Centrioles and cilia are microtubule-based structures, whose precise formation requires controlled cytoplasmic tubulin incorporation. How cytoplasmic tubulin is recognized for centriolar/ciliary-microtubule construction remains poorly understood. Centrosomal-P4.1-associated-protein (CPAP) binds tubulin via its PN2-3 domain. Here, we show that a C-terminal loop-helix in PN2-3 targets β-tubulin at the microtubule...
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