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Article

14-3-3γ prevents centrosome duplication by inhibiting NPM1 function.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jun 2021

Bose Arunabha, Modi Kruti, Dey Suchismita, Dalvi Somavally, Nadkarni Prafful, Sudarshan Mukund, Kundu Tapas K, Venkatraman Prasanna, Dalal Sorab N

Abstract excerpt

14-3-3 proteins bind to ligands via phospho-serine containing consensus motifs. However, the molecular mechanisms underlying complex formation and dissociation between 14-3-3 proteins and their ligands remain unclear. We identified two conserved acidic residues in the 14-3-3 peptide-binding pocket (D129 and E136) that potentially regulate complex formation and dissociation. Altering these residues to alanine led...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33813791
DOI: 10.1111/gtc.12848

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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