Article
II. Correlations between secondary structure stability and mutation frequency during somatic hypermutation.
Molecular immunology - 1 Aug 2008
Wright Barbara E, Schmidt Karen H, Davis Nick, Hunt Aaron T, Minnick Michael F
Abstract excerpt
The role of secondary structures and base mutability at different levels of transcription and supercoiling is analyzed in variable region antibody genes VH5, VH94 and VH186.2. The data are consistent with a model of somatic hypermutation in which increasing levels of transcription and secondary structure stability correlate with the initial formation of successive mutable sites. Encoded differences exist in stem...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.