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Article

Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.

Journal of bacteriology - 1 Oct 2002

Fleischmann R D, Alland D, Eisen J A, Carpenter L, White O, Peterson J, DeBoy R, Dodson R, Gwinn M, Haft D, Hickey E, Kolonay J F, Nelson W C, Umayam L A, Ermolaeva M, Salzberg S L, Delcher A, Utterback T, Weidman J, Khouri H, Gill J, Mikula A, Bishai W, Jacobs W R, Venter J C, Fraser C M

Abstract excerpt

Virulence and immunity are poorly understood in Mycobacterium tuberculosis. We sequenced the complete genome of the M. tuberculosis clinical strain CDC1551 and performed a whole-genome comparison with the laboratory strain H37Rv in order to identify polymorphic sequences with potential relevance to disease pathogenesis, immunity, and evolution. We found large-sequence and single-nucleotide polymorphisms in...

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Identifiers

PMID: 12218036
DOI: 10.1128/JB.184.19.5479-5490.2002
PMCID: PMC135346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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