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Article

SMRT genome assembly corrects reference errors, resolving the genetic basis of virulence in Mycobacterium tuberculosis.

BMC genomics - 17 Apr 2017

Elghraoui Afif, Modlin Samuel J, Valafar Faramarz

Abstract excerpt

BACKGROUND: The genetic basis of virulence in Mycobacterium tuberculosis has been investigated through genome comparisons of virulent (H37Rv) and attenuated (H37Ra) sister strains. Such analysis, however, relies heavily on the accuracy of the sequences. While the H37Rv reference genome has had several corrections to date, that of H37Ra is unmodified since its original publication. RESULTS: Here, we report the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28415976
DOI: 10.1186/s12864-017-3687-5
PMCID: PMC5393005

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