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Comparative analysis of genomic characteristics and immune response between Mycobacterium tuberculosis strains cultured continuously for 25 years and H37Rv.

Pathogens and disease - 7 Feb 2024

Zhu Chuanzhi, Dong Jing, Duan Yuheng, Jia Hongyan, Zhang Lanyue, Xing Aiying, Du Boping, Sun Qi, Huang Yinxia, Zhang Zongde, Pan Liping, Li Zihui

Abstract excerpt

Tuberculosis (TB) continues to pose a significant global health challenge, emphasizing the critical need for effective preventive measures. Although many studies have tried to develop new attenuated vaccines, there is no effective TB vaccine. In this study, we report a novel attenuated Mycobacterium tuberculosis (M. tb) strain, CHVAC-25, cultured continuously for 25 years in the laboratory. CHVAC-25 exhibited...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38845379
DOI: 10.1093/femspd/ftae014
PMCID: PMC11187990

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