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Article

ANP32A-mediated histone 3 K27 acetylation is essential for sotorasib activity in KRAS-mutant non-small cell lung cancer.

The Journal of biological chemistry - 1 Feb 2026

Pan Kailing, Dang Mingjing, Xu Bo, Huang Zan, Chen Xianguo

Abstract excerpt

Drug resistance is a major challenge for the target therapy of KRAS-mutant non-small cell lung cancer (NSCLC). Here, we observe that ANP32A is tightly associated with KRAS-mutant NSCLC and serves as an unfavorable prognosis factor. ANP32A deficiency impaired cell proliferation, migration, invasion, and cell cycle progression and induced sotorasib (Sot) resistance in KRAS-mutant NSCLC cells, which were reversed by...

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Identifiers

PMID: 41475546
DOI: 10.1016/j.jbc.2025.111110
PMCID: PMC12857290

Genes

ANP32A
KRAS
YEATS4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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