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PRR11 and SKA2 gene pair is overexpressed and regulated by p53 in breast cancer

28 Feb 2019

Abstract excerpt

Our previous study found that two novel cancer-related genes, PRR11 and SKA2, constituted a classic gene pair that was regulated by p53 and NF-Y in lung cancer. However, their role and regulatory mechanism in breast cancer remain elusive. In this study, we found that the expression levels of PRR11 and SKA2 were upregulated and have a negative prognotic value in breast cancer. Loss-of-function experiments showed...

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PMID: 30760381
DOI: 10.5483/bmbrep.2019.52.2.207

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