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Article

A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation.

Oncogene - 25 Jan 2018

Chhabra Y, Wong H Y, Nikolajsen L F, Steinocher H, Papadopulos A, Tunny K A, Meunier F A, Smith A G, Kragelund B B, Brooks A J, Waters M J

Abstract excerpt

Both humans and mice lacking functional growth hormone (GH) receptors are known to be resistant to cancer. Further, autocrine GH has been reported to act as a cancer promoter. Here we present the first example of a variant of the GH receptor (GHR) associated with cancer promotion, in this case lung cancer. We show that the GHRP495T variant located in the receptor intracellular domain is able to prolong the GH...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28967904
DOI: 10.1038/onc.2017.352
PMCID: PMC5799715

Genes

SOCS2
GHR
CCND1
EGFR
MYC
SNAI2
TWIST1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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