Article
CTLA-4 gene polymorphisms predispose to autoimmune endocrinopathies but not to celiac disease.
Neuro endocrinology letters - 1 Jun 2008
Dallos Tomás, Avbelj Magdalena, Barák L'ubomír, Zapletalová Jirina, Pribilincová Zuzana, Krajcírová Mária, Kostálová L'udmila, Battelino Tadej, Kovács László
Abstract excerpt
OBJECTIVES: The aim of the study was to determine the association of two CTLA-4 gene polymorphisms (CT60, +49 A/G) with Hashimoto thyroiditis (HT), type 1 diabetes mellitus (T1DM) and celiac disease (CD) as well as with the occurrence of multi-organ involvement by autoimmunity in children. METHODS: Genotyping was done by RFLP analysis in Slovak children with HT (n=63) and CD (n=120) and both Slovak and Slovene...
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