Article
A common CTLA4 polymorphism confers susceptibility to autoimmune thyroid disease in celiac children.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 1 Jun 2009
Tolone C, Cirillo G, Papparella A, Tolone S, Santoro N, Grandone A, Perrone L, del Giudice E Miraglia
Abstract excerpt
BACKGROUND: Cytotoxic T-lymphocyte-associated protein 4 (CTLA4) is a strong candidate gene in autoimmunity susceptibility. In particular, the CTLA4 CT60 A/G dimorphism has been associated with celiac disease (CD) and was reported to be strongly associated with autoimmune thyroid disease (AITD). AIMS: This study aimed to investigate the possible influences of the CTLA4 CT60 A/G polymorphism in the susceptibility...
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