Article
CTLA-4 polymorphisms (+49 A/G and -318 C/T) are important genetic determinants of AITD susceptibility and predisposition to high levels of thyroid autoantibodies in Polish children - preliminary study.
Acta biochimica Polonica - 1 Jan 2013
Pastuszak-Lewandoska Dorota, Domańska Daria, Rudzińska Magdalena, Bossowski Artur, Kucharska Anna, Sewerynek Ewa, Czarnecka Karolina, Migdalska-Sęk Monika, Czarnocka Barbara
Abstract excerpt
Autoimmune thyroid diseases (AITDs), including Hashimoto' s thyroiditis (HT) and Graves' disease (GD), are related to environmental and genetic factors. We analyzed the association of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) gene two polymorphisms (+49 A/G, -318 C/T) with HT and GD development in Polish children, and correlated both polymorphisms with the production of thyroid autoantibodies (TPOAb...
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