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Article

Evidence for a new tumor-suppressor gene involved in gastrointestinal malignancies.

Surgery - 1 Aug 1991

Wasylyshyn M L, Neuman W L, Angriman I, Snyder L A, Montag A G, Westbrook C A, Michelassi F

Abstract excerpt

Inactivation or loss of tumor-suppressor genes is believed to lead to the development or progression of malignancies. To determine whether a tumor-suppressor gene is located on chromosome 8, DNA was extracted from tumor and normal tissue of colorectal, gastric, and pancreatic specimens, and allele loss was investigated by Southern hybridization techniques with the chromosome 8 probe D8S7. Twenty-five percent of...

Topics

Adenocarcinoma
Alleles
Blotting, Southern
Chromosome Deletion
Chromosomes, Human, Pair 8
DNA Probes
Gastrointestinal Neoplasms
Genes, Tumor Suppressor
Humans
Pancreatic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 1858037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1858037-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Evidence for a new tumor-suppressor gene involved in gastrointestinal malignancies.PMID 1858037Read ↗

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