Article
Dietary salt induces transcription of the prostaglandin transporter gene in renal collecting ducts.
American journal of physiology. Renal physiology - 1 Sept 2008
Chi Yuling, Pucci Michael L, Schuster Victor L
Abstract excerpt
Prostaglandin E(2) (PGE(2)) plays an important role in maintaining body fluid homeostasis by activating its receptors on the renal collecting duct (CD) to stimulate renal Na(+) and water excretion. The PG carrier prostaglandin transporter (PGT) is expressed on the CD apical membrane, where it mediates PG reuptake as part of the termination of autocrine PG signaling. Here we tested the hypothesis that dietary salt...
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