Article
Mutation at residue 523 creates a second receptor binding site on human parainfluenza virus type 1 hemagglutinin-neuraminidase protein.
Journal of virology - 1 Sept 2006
Bousse Tatiana, Takimoto Toru
Abstract excerpt
The paramyxovirus hemagglutinin-neuraminidase (HN) is a multifunctional protein mediating hemagglutination (HA), neuraminidase (NA), and fusion promotion activities. It has been a matter of debate whether HN contains combined or separate sites for HA and NA activities. To clear the issue, we dete...
Topics
- Amino Acid Sequence
- Binding Sites
- Catalytic Domain
- Erythrocytes
- HN Protein
- HeLa Cells
- Humans
- Kinetics
- Molecular Sequence Data
- Mutation
- Parainfluenza Virus 1, Human
- Protein Binding
- Recombinant Fusion Proteins
- Sequence Homology, Amino Acid