Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure.

PLoS medicine - 24 Jun 2008

Bisgaard Hans, Simpson Angela, Palmer Colin N A, Bønnelykke Klaus, McLean Irwin, Mukhopadhyay Somnath, Pipper Christian B, Halkjaer Liselotte B, Lipworth Brian, Hankinson Jenny, Woodcock Ashley, Custovic Adnan

Abstract excerpt

BACKGROUND: Loss-of-function variants in the gene encoding filaggrin (FLG) are major determinants of eczema. We hypothesized that weakening of the physical barrier in FLG-deficient individuals may potentiate the effect of environmental exposures. Therefore, we investigated whether there is an interaction between FLG loss-of-function mutations with environmental exposures (pets and dust mites) in relation to the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cats
Share to Codon, Nonsense

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dermatitis, Atopic

Share to Environmental Exposure

Share to Filaggrin Proteins

Share to Intermediate Filament Proteins

Share to Parturition

Source

Open in PubMed Open full text

Identifiers

PMID: 18578563
DOI: 10.1371/journal.pmed.0050131
PMCID: PMC2504043

Genes

FLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure.PMID 18578563Read ↗

Filaggrin mutations in the onset of eczema, sensitization, asthma, hay fever and the interaction with cat exposure.Semantic proximity Read ↗

Risk analysis of early childhood eczema.Semantic proximity Read ↗

An interaction between filaggrin mutations and early food sensitization improves the prediction of childhood asthma.Semantic proximity Read ↗

The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study.Semantic proximity Read ↗

Filaggrin gene variants and atopic diseases in early childhood assessed longitudinally from birth.Semantic proximity Read ↗

Interplay of filaggrin loss-of-function variants, allergic sensitization, and eczema in a longitudinal study covering infancy to 18 years of age.Semantic proximity Read ↗

Filaggrin mutations in relation to skin barrier and atopic dermatitis in early infancy.Semantic proximity Read ↗

Genetic predisposition and environmental factors associated with the development of atopic dermatitis in infancy: a prospective birth cohort study.Semantic proximity Read ↗

Domestic dog exposure at birth reduces the incidence of atopic dermatitis.Semantic proximity Read ↗

What is the evidence for interactions between filaggrin null mutations and environmental exposures in the aetiology of atopic dermatitis? A systematic review.Semantic proximity Read ↗

Filaggrin mutations increase allergic airway disease in childhood and adolescence through interactions with eczema and aeroallergen sensitization.Semantic proximity Read ↗

Gene-Environment Interaction Affects Risk of Atopic Eczema: Population and In Vitro Studies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.