Article
Gene-Environment Interaction Affects Risk of Atopic Eczema: Population and In Vitro Studies.
Allergy - 1 Aug 2025
Standl Marie, Budu-Aggrey Ashley, Johnston Luke J, Elias Martina S, Arshad S Hasan, Bager Peter, Bataille Veronique, Blakeway Helena, Bønnelykke Klaus, Boomsma Dorret, Brumpton Ben M, Bustamante Pineda Mariona, Campbell Archie, Curtin John A, Eliasen Anders, Fadista João P S, Feenstra Bjarke, Gerner Trine, Medina-Gomez Carolina, Grosche Sarah, Gutzkow Kristine B, Halling Anne-Sofie, Hayward Caroline, Henderson John, Herrera-Luis Esther, Holloway John W, Hottenga Joukejan, O'B Hourihane Jonathan, Hu Chen, Hveem Kristian, Irizar Amaia, Jacquemin Bénédicte, Jessen Leon, Kress Sara, Kurukulaaratchy Ramesh J, Lau Susanne, Llop Sabrina, Løset Mari, Marenholz Ingo, Mason Dan, McCartney Daniel L, Melbye Mads, Melén Erik, Minica Camelia, Murray Clare S, Nijsten Tamar, Pardo Luba M, Pasmans Suzanne, Pennell Craig E, Rinnov Maria R, Santorelli Gillian, Schikowski Tamara, Sheehan Darina, Simpson Angela, Söderhäll Cilla, Thomas Laurent F, Thyssen Jacob P, Torrent Maties, van Beijsterveldt Toos, Visconti Alessia, Vonk Judith M, Wang Carol A, Xu Cheng-Jian, Ziyab Ali H, Custovic Adnan, Di Meglio Paola, Duijts Liesbeth, Flohr Carsten, Irvine Alan D, Koppelman Gerard H, Lee Young-Ae, Reynolds Nick J, Smith Catherine, Langan Sinéad M, Paternoster Lavinia, Brown Sara J
Abstract excerpt
BACKGROUND: Multiple environmental and genetic factors play a role in the pathogenesis of atopic eczema (AE). We aimed to investigate gene-environment interactions (G × E) to improve understanding of the pathophysiology. METHODS: We analysed data from 16 European studies to test for interaction between the 24 most significant AE-associated loci identified from genome-wide association studies and 18 early-life...
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