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Article

MicroRNA-34a is an important component of PRIMA-1-induced apoptotic network in human lung cancer cells.

International journal of cancer - 15 Jul 2010

Duan Wenrui, Gao Li, Wu Xin, Wang Li, Nana-Sinkam Serge P, Otterson Gregory A, Villalona-Calero Miguel A

Abstract excerpt

Restoration of p53 function in tumor cells would be an attractive strategy for lung cancer therapy because p53 mutations are found in more than 50% of lung cancers. The small molecule PRIMA-1 has been shown to restore the tumor suppression function of p53 and to induce apoptosis in human tumor cells. The mechanism of apoptosis induced by PRIMA-1 remains unclear. We investigated the effects of PRIMA-1 in apoptosis...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19921694
DOI: 10.1002/ijc.25049
PMCID: PMC4153870

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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