Article
Radiation-induced apoptosis of tumor cells is facilitated by inhibition of the interaction between Survivin and Smac/DIABLO.
Cancer letters - 18 Jan 2008
Ogura Aki, Watanabe Yasuko, Iizuka Daisuke, Yasui Hironobu, Amitani Makoto, Kobayashi Saori, Kuwabara Mikinori, Inanami Osamu
Abstract excerpt
To investigate the mechanism of radioresistance of solid tumor cells, we created two expression vectors encoding Survivin mutants, T34A and D53A. When T34A and D53A were overexpressed in NIH3T3, A549 and HeLa cells, radiation-induced apoptosis was significantly enhanced. Furthermore, we examined the binding capability of Survivin with Smac/DIABLO in the cells that overexpressed these mutants....
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