Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impaired learning and memory in Pitx3 deficient aphakia mice: a genetic model for striatum-dependent cognitive symptoms in Parkinson's disease.

Neurobiology of disease - 1 Sept 2008

Ardayfio Paul, Moon Jisook, Leung Ka Ka Amanda, Youn-Hwang Dong, Kim Kwang-Soo

Abstract excerpt

Disorders of the basal ganglia such as Parkinson's disease (PD) and Huntington's disease are commonly thought of primarily as motor disorders; however, the cognitive symptoms of these diseases such as executive dysfunction, learning, memory and attention deficits are prominent and often more disabling than the hallmark motor symptoms. Cognitive features of PD are often neglected in preclinical studies of PD,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Avoidance Learning
Share to Corpus Striatum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Feeding Behavior

Share to Learning Disabilities

Share to Maze Learning

Share to Memory Disorders

Share to Mice, Neurologic Mutants

Share to Social Behavior

Source

Open in PubMed Open full text

Identifiers

PMID: 18573342
DOI: 10.1016/j.nbd.2008.05.017
PMCID: PMC2594011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired learning and memory in Pitx3 deficient aphakia mice: a genetic model for striatum-dependent cognitive symptoms in Parkinson's disease.PMID 18573342Read ↗

Behavioral phenotyping of Parkin-deficient mice: looking for early preclinical features of Parkinson's disease.Semantic proximity Read ↗

Striatal neuroadaptation and rescue of locomotor deficit by L-dopa in aphakia mice, a model of Parkinson's disease.Semantic proximity Read ↗

3,4-Dihydroxyphenylalanine Reverses the Motor Deficits in Pitx3-Deficient<i>Aphakia</i>Mice: Behavioral Characterization of a Novel Genetic Model of Parkinson's DiseaseSemantic proximity Read ↗

Behavioral Phenotyping in a Murine Model of GBA1-Associated Parkinson Disease.Semantic proximity Read ↗

Neurobehavioral Anomalies in the Pitx3/ak Murine Model of Parkinson's Disease and MPTP.Semantic proximity Read ↗

Spontaneous object exploration in a recessive gene knockout model of Parkinson’s disease: Development and progression of object recognition memory deficits in male <i>Pink1</i> -/- ratsSemantic proximity Read ↗

Sex differences distinguish performance in four object recognition-based memory tasks in the Pink1-/- rat model of Parkinson’s diseaseSemantic proximity Read ↗

A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 MiceSemantic proximity Read ↗

Phenotypic segregation of aphakia and Pitx3-null mutants reveals that Pitx3 deficiency increases consolidation of specific movement components.Semantic proximity Read ↗

Drosophila PINK1 and parkin loss-of-function mutants display a range of non-motor Parkinson's disease phenotypes.Semantic proximity Read ↗

Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP, PS1, and Mapt (3xTg-AD).Semantic proximity Read ↗

Cognitive deficits and altered cholinergic innervation in young adult male mice carrying a Parkinson's disease Lrrk2G2019S knockin mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.