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Article

Neurobehavioral Anomalies in the Pitx3/ak Murine Model of Parkinson's Disease and MPTP.

Behavior genetics - 1 Mar 2016

Filali Mohammed, Lalonde Robert

Abstract excerpt

Pitx3/ak null mutants are characterized by basal ganglia pathology in a manner resembling Parkinson's disease (PD), with decline in substantia nigra cell numbers as well as striatal tyrosine hydroxylase expression. Although young adult Pitx3/ak mutants were deficient in motor coordination tests, they were more active than non-transgenic controls in the open-field, unlike PD-related bradykinesia. On the SHIRPA...

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Identifiers

PMID: 26477573
DOI: 10.1007/s10519-015-9753-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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