Article
A Bayesian spatial multimarker genetic random-effect model for fine-scale mapping.
Annals of human genetics - 1 Sept 2008
Tsai M-Y, Hsiao C K, Wen S-H
Abstract excerpt
Multiple markers in linkage disequilibrium (LD) are usually used to localize the disease gene location. These markers may contribute to the disease etiology simultaneously. In contrast to the single-locus tests, we propose a genetic random effects model that accounts for the dependence between loci via their spatial structures. In this model, the locus-specific random effects measure not only the genetic disease...
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