Article
Deletion of Glu155 causes a deficiency of glutathione transferase Omega 1-1 but does not alter sensitivity to arsenic trioxide and other cytotoxic drugs.
The international journal of biochemistry & cell biology - 1 Jan 2008
Schmuck Erica, Cappello Jean, Coggan Marjorie, Brew Jenny, Cavanaugh Juleen A, Blackburn Anneke C, Baker Rohan T, Eyre Helen J, Sutherland Grant R, Board Philip G
Abstract excerpt
The Omega class glutathione transferase GSTO1-1 can catalyze the reduction of pentavalent methylated arsenic species and is responsible for the biotransfomation of potentially toxic alpha-haloketones. We investigated the cause of GSTO1-1 deficiency in the T-47D breast cancer cell line and found that the cell line is hemizygous for a polymorphic allele that encodes the deletion of Glu155. Northern and Western...
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