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Article

Single-nucleotide polymorphic variants of human glutathione transferase T1-1 differ in stability and functional properties.

Archives of biochemistry and biophysics - 1 Oct 2009

Josephy P David, Kent Meredith, Mannervik Bengt

Abstract excerpt

We have previously expressed hexa-histidine-tagged human glutathione transferase GST T1-1 at very high levels in an Escherichia colilacZ mutagenicity assay strain. Ethylene dibromide (EDB), which is activated by GST T1-1, produces a potent response in the mutation assay. We have now constructed and expressed two SNP variants of wild-type GST T1-1:D141N and E173K. The EDB activation activities of both variant...

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Source

Identifiers

PMID: 19664997
DOI: 10.1016/j.abb.2009.07.025

Genes

GSTT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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