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Article

Defining the binding site of levosimendan and its analogues in a regulatory cardiac troponin C-troponin I complex.

Biochemistry - 15 Jul 2008

Robertson Ian M, Baryshnikova Olga K, Li Monica X, Sykes Brian D

Abstract excerpt

The interaction of Cardiac Troponin C (cTnC) and Cardiac Troponin I (cTnI) plays a critical role in transmitting the Ca (2+) signal to the other myofilament proteins in the activation of cardiac muscle contraction. As such, the cTnC-cTnI interface is a logical target for cardiotonic agents such as levosimendan that can modulate the Ca (2+) sensitivity of the myofilaments. Evidence indicates that drug candidates...

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Identifiers

PMID: 18570382
DOI: 10.1021/bi800438k
PMCID: PMC2652250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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