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Article

Phosphorylation-induced distance change in a cardiac muscle troponin I mutant.

Biochemistry - 3 Jun 1997

Dong W J, Chandra M, Xing J, She M, Solaro R J, Cheung H C

Abstract excerpt

Phosphorylation of two adjacent serine residues in the unique N-terminal extension of cardiac muscle troponin I (cTnI) is known to decrease the Ca2+-sensitivity of cardiac myofilaments. To probe the structural significance of the N-terminal extension, we have constructed two cTnI mutants each containing a single cysteine: (1) a full-length cTnI mutant (S5C/C81I/C98S) and (2) a truncated cTnI mutant...

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Identifiers

PMID: 9184157
DOI: 10.1021/bi9622276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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