Phosphorylation-induced distance change in a cardiac muscle troponin I mutant.

doi:10.1021/bi9622276

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Article

Phosphorylation-induced distance change in a cardiac muscle troponin I mutant.

Biochemistry - 3 Jun 1997

Dong W J, Chandra M, Xing J, She M, Solaro R J, Cheung H C

Abstract excerpt

Phosphorylation of two adjacent serine residues in the unique N-terminal extension of cardiac muscle troponin I (cTnI) is known to decrease the Ca2+-sensitivity of cardiac myofilaments. To probe the structural significance of the N-terminal extension, we have constructed two cTnI mutants each con...

Topics

Animals
Calcium
Cattle
Chemical Phenomena
Chemistry, Physical
Egtazic Acid
Fluorescent Dyes
Magnesium
Mathematics
Mutation
Myocardium
Naphthalenesulfonates
Phosphorylation
Phosphoserine
Spectrometry, Fluorescence
Structure-Activity Relationship
Thermodynamics
Troponin C

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Open in PubMed

Identifiers

PMID: 9184157
DOI: 10.1021/bi9622276

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9184157-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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