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Article

Organization of the gene for platelet glycoprotein IIb.

Biochemistry - 6 Feb 1990

Heidenreich R, Eisman R, Surrey S, Delgrosso K, Bennett J S, Schwartz E, Poncz M

Abstract excerpt

The glycoprotein (GP) IIb/IIIa heterodimer functions as a receptor for fibrinogen, von Willebrand factor, and fibronectin on activated platelets; it is dysfunctional in the bleeding diathesis Glanzmann's thrombasthenia. This receptor is a member of the integrin family, which includes homologous membrane receptors involved in a number of different cell-cell and cell-matrix adhesive interactions. Knowledge of the...

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Identifiers

PMID: 2322558
DOI: 10.1021/bi00457a020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Organization of the gene for platelet glycoprotein IIb.PMID 2322558Read ↗

Identification of an abnormal gene for the GPIIIa subunit of the platelet fibrinogen receptor resulting in Glanzmann's thrombasthenia.Semantic proximity Read ↗

Beta2-glycoprotein I and its clinical significance: from gene sequence to protein levels.Semantic proximity Read ↗

A 10-base-pair deletion in the gene encoding platelet glycoprotein IIb associated with Glanzmann thrombasthenia in a horse.Semantic proximity Read ↗

Glanzmann's thrombasthenia associated with deletion-insertion and alternative splicing in the glycoprotein IIb gene.Semantic proximity Read ↗

The molecular genetic basis of Glanzmann thrombasthenia in the Iraqi-Jewish and Arab populations in Israel.Semantic proximity Read ↗

Role of the transmembrane and cytoplasmic domains in the assembly and surface exposure of the platelet integrin GPIIb/IIIa.Semantic proximity Read ↗

Two Genetic Defects in αIIb Are Associated with Type I Glanzmann's Thrombasthenia in a Great Pyrenees Dog: A 14-base Insertion in Exon 13 and a Splicing Defect of Intron 13Semantic proximity Read ↗

A novel homozygous mutation (1619delC) in GPIIb gene associated with Glanzmann thrombasthenia, the decay of GPIIb-mRNA and the synthesis of a truncated GPIIb unable to form complex with GPIIIa.Semantic proximity Read ↗

Identification of Essential GATA and Ets Binding Motifs within the Promoter of the Platelet Glycoprotein Ibα GeneSemantic proximity Read ↗

Localization of the Br polymorphism on a 144 bp exon of the GPIa gene and its application in platelet DNA typing.Semantic proximity Read ↗

Glanzmann thrombasthenia resulting from a single amino acid substitution between the second and third calcium-binding domains of GPIIb. Role of the GPIIb amino terminus in integrin subunit association.Semantic proximity Read ↗

Identification of a nonsense mutation at amino acid 584-arginine of platelet glycoprotein IIb in patients with type I Glanzmann thrombasthenia.Semantic proximity Read ↗

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