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Article

Organization of the gene for platelet glycoprotein IIb.

Biochemistry - 6 Feb 1990

Heidenreich R, Eisman R, Surrey S, Delgrosso K, Bennett J S, Schwartz E, Poncz M

Abstract excerpt

The glycoprotein (GP) IIb/IIIa heterodimer functions as a receptor for fibrinogen, von Willebrand factor, and fibronectin on activated platelets; it is dysfunctional in the bleeding diathesis Glanzmann's thrombasthenia. This receptor is a member of the integrin family, which includes homologous membrane receptors involved in a number of different cell-cell and cell-matrix adhesive interactions. Knowledge of the...

Topics

Amino Acid Sequence
Base Sequence
Blood Platelets
Cloning, Molecular
DNA
Exons
Genetic Markers
Humans
Introns
Molecular Sequence Data
Multigene Family
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Platelet Membrane Glycoproteins

RNA, Messenger

Source

Identifiers

PMID: 2322558
DOI: 10.1021/bi00457a020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2322558-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

Organization of the gene for platelet glycoprotein IIb.PMID 2322558Read ↗

Identification of an abnormal gene for the GPIIIa subunit of the platelet fibrinogen receptor resulting in Glanzmann's thrombasthenia.Semantic proximity Read ↗

Beta2-glycoprotein I and its clinical significance: from gene sequence to protein levels.Semantic proximity Read ↗

A 10-base-pair deletion in the gene encoding platelet glycoprotein IIb associated with Glanzmann thrombasthenia in a horse.Semantic proximity Read ↗

Glanzmann's thrombasthenia associated with deletion-insertion and alternative splicing in the glycoprotein IIb gene.Semantic proximity Read ↗

The molecular genetic basis of Glanzmann thrombasthenia in the Iraqi-Jewish and Arab populations in Israel.Semantic proximity Read ↗

Role of the transmembrane and cytoplasmic domains in the assembly and surface exposure of the platelet integrin GPIIb/IIIa.Semantic proximity Read ↗

Two Genetic Defects in αIIb Are Associated with Type I Glanzmann's Thrombasthenia in a Great Pyrenees Dog: A 14-base Insertion in Exon 13 and a Splicing Defect of Intron 13Semantic proximity Read ↗

A novel homozygous mutation (1619delC) in GPIIb gene associated with Glanzmann thrombasthenia, the decay of GPIIb-mRNA and the synthesis of a truncated GPIIb unable to form complex with GPIIIa.Semantic proximity Read ↗

Identification of Essential GATA and Ets Binding Motifs within the Promoter of the Platelet Glycoprotein Ibα GeneSemantic proximity Read ↗

Localization of the Br polymorphism on a 144 bp exon of the GPIa gene and its application in platelet DNA typing.Semantic proximity Read ↗

Glanzmann thrombasthenia resulting from a single amino acid substitution between the second and third calcium-binding domains of GPIIb. Role of the GPIIb amino terminus in integrin subunit association.Semantic proximity Read ↗

Identification of a nonsense mutation at amino acid 584-arginine of platelet glycoprotein IIb in patients with type I Glanzmann thrombasthenia.Semantic proximity Read ↗

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