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Article

Statistical methods for detecting genetic interactions: a head and neck squamous-cell cancer study.

Journal of toxicology and environmental health. Part A - 1 Jan 2008

Ickstadt Katja, Schäfer Martin, Fritsch Arno, Schwender Holger, Abel Josef, Bolt Hermann M, Brüning Thomas, Ko Yon-Dschun, Vetter Hans, Harth Volker

Abstract excerpt

Tobacco smoke and occupational exposures to chemicals such as polycyclic aromatic hydrocarbons (PAHs) are, aside from alcohol, the major risk factors for development of head and neck squamous-cell cancer (HNSCC). In this study, new statistical methods were applied. We employ new statistical methods to detect genetic interactions perhaps of higher order, that might play a role in developing HNSCC. The underlying...

Read the complete abstract on PubMed

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Share to Aryl Hydrocarbon Hydroxylases
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP1B1

Share to Data Interpretation, Statistical

Share to Glutathione Transferase

Share to Head and Neck Neoplasms

Share to Models, Statistical

Share to Tobacco Use Disorder

Source

Identifiers

PMID: 18569579
DOI: 10.1080/15287390801985745

Genes

GSTP1
PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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