Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interaction of cytochrome P450s with environmental risk factors increases their expression and risk to head and neck cancer.

Environmental and molecular mutagenesis - 1 Jun 2022

Katiyar Tridiv, Yadav Vinay, Maurya Shailendra S, Hasan Feza, Singh Arvind P, Yadav Sanjay, Singh Sudhir, Hadi Rahat, Bhatt Madan Lal B, Parmar Devendra

Abstract excerpt

To investigate the role of interaction of tobacco metabolizing polymorphic cytochrome P450s (CYPs) and glutathione S-transferase M1 (GSTM1) with environmental risk factors in modifying the susceptibility to head and neck squamous cell carcinoma (HNSCC), a case-control study with 1250 proven cases of HNSCC and equal number of healthy controls was planned. A small but significant increase in the risk to HNSCC (1-2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Drinking
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 Enzyme System

Share to Genetic Predisposition to Disease

Share to Glutathione Transferase

Share to Head and Neck Neoplasms

Share to Risk Factors

Share to Squamous Cell Carcinoma of Head and Neck

Source

Identifiers

PMID: 35638572
DOI: 10.1002/em.22495

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction of cytochrome P450s with environmental risk factors increases their expression and risk to head and neck cancer.PMID 35638572Read ↗

Interaction of glutathione-s-transferase genotypes with environmental risk factors in determining susceptibility to head and neck cancer and treatment response and survival outcome.Semantic proximity Read ↗

Polymorphisms in drug-metabolizing enzymes and risk to head and neck cancer: evidence for gene-gene and gene-environment interaction.Semantic proximity Read ↗

Cytochrome P450 2E1 and head and neck cancer: interaction with genetic and environmental risk factors.Semantic proximity Read ↗

Combined effect of smoking and polymorphisms in tobacco carcinogen-metabolizing enzymes CYP1A1 and GSTM1 on the head and neck cancer risk in North Indians.Semantic proximity Read ↗

Polymorphism in cytochrome P4501A1 is significantly associated with head and neck cancer risk.Semantic proximity Read ↗

Polymorphism in cytochrome P450 1A2 and their interaction with risk factors in determining risk of squamous cell lung carcinoma in men.Semantic proximity Read ↗

Risk modulation of GSTM1–GSTT1 interactions to head and neck cancer in tobacco users.Semantic proximity Read ↗

Genetic polymorphism of CYP genes, alone or in combination, as a risk modifier of tobacco-related cancers.Semantic proximity Read ↗

Polymorphism in cytochrome P450 2A6 and glutathione S-transferase P1 modifies head and neck cancer risk and treatment outcome.Semantic proximity Read ↗

Tobacco carcinogen-metabolizing genes CYP1A1, GSTM1, and GSTT1 polymorphisms and their interaction with tobacco exposure influence the risk of head and neck cancer in Northeast Indian population.Semantic proximity Read ↗

Smoking related risk involved in individuals carrying genetic variants of CYP1A1 gene in head and neck cancer.Semantic proximity Read ↗

CYP1A2*1C, CYP2E1*5B, and GSTM1 polymorphisms are predictors of risk and poor outcome in head and neck squamous cell carcinoma patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.