Some genetic considerations for the design of better mammalian assay systems for the detection of chemical mutagens and carcinogens.

Abstract excerpt

Fuller utilization of the potential for genetic manipulation of the laboratory animal populations producing test animals should aid in the development of more sensitive, relevant, and economic toxicologic assay systems for the generation of dose response data at environmental exposure levels. One example of such genetic manipulation is the incorporation, in laboratory mouse populations of any desired genetic...

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