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Article

Atypical gating of M-type potassium channels conferred by mutations in uncharged residues in the S4 region of KCNQ2 causing benign familial neonatal convulsions.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 May 2007

Soldovieri Maria Virginia, Cilio Maria Roberta, Miceli Francesco, Bellini Giulia, Miraglia del Giudice Emanuele, Castaldo Pasqualina, Hernandez Ciria C, Shapiro Mark S, Pascotto Antonio, Annunziato Lucio, Taglialatela Maurizio

Abstract excerpt

Heteromeric assembly of KCNQ2 and KCNQ3 subunits underlie the M-current (I(KM)), a slowly activating and noninactivating neuronal K(+) current. Mutations in KCNQ2 and KCNQ3 genes cause benign familial neonatal convulsions (BFNCs), a rare autosomal-dominant epilepsy of the newborn. In the present...

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Source

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Identifiers

PMID: 17475800
DOI: 10.1523/JNEUROSCI.0580-07.2007
PMCID: PMC6672104

Genes

KCNQ2
KCNQ3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17475800-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Atypical gating of M-type potassium channels conferred by mutations in uncharged residues in the S4 region of KCNQ2 causing benign familial neonatal convulsions.PMID 17475800Read ↗

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