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Article

Identification of specific pore residues mediating KCNQ1 inactivation. A novel mechanism for long QT syndrome.

The Journal of biological chemistry - 27 Apr 2001

Seebohm G, Scherer C R, Busch A E, Lerche C

Abstract excerpt

KCNQ1 inactivation bears electrophysiological characteristics different from classical N- and C-type inactivation in Shaker-like potassium channels. However, the molecular site of KCNQ1 inactivation has not yet been determined. KCNQ2 channels do not exert a fast inactivation in contrast to KCNQ1 channels. By expressing functional chimeras between KCNQ1 and KCNQ2 in Xenopus oocytes, we mapped the region of this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11278406
DOI: 10.1074/jbc.M008373200

Genes

KCNQ1
KCNQ2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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