Article
Variations in mitochondrial DNA copy numbers in MS brains.
Journal of molecular neuroscience : MN - 1 Jul 2008
Blokhin Andrei, Vyshkina Tamara, Komoly Samuel, Kalman Bernadette
Abstract excerpt
The aim of this study is to determine if there is a pathology-related variation in mitochondrial (mt)DNA copy numbers in brains of patients with multiple sclerosis (MS). Our recent study demonstrated an age-dependent but excluded a MS pathology-related increase in the proportion of cytochrome oxidase (COX)-negative cells and deleted mtDNA molecules in postmortem brain tissue specimens of patients and controls...
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