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Article

Chemopreventive effects of gefitinib on nonsmoking-related lung tumorigenesis in activating epidermal growth factor receptor transgenic mice.

Cancer research - 1 Sept 2009

Ohashi Kadoaki, Takigawa Nagio, Osawa Masahiro, Ichihara Eiki, Takeda Hiromasa, Kubo Toshio, Hirano Seiki, Yoshino Tadashi, Takata Minoru, Tanimoto Mitsune, Kiura Katsuyuki

Abstract excerpt

Twenty-five percent of all lung cancer cases are not attributable to smoking. Epidermal growth factor receptor (EGFR) mutations, which are involved in approximately 50% of nonsmoker lung cancer, are positively correlated with responsiveness to gefitinib, and inversely correlated with smoking history. Activating EGFR mutations play a critical role in the carcinogenesis of nonsmoking-related lung cancer. To...

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PMID: 19690148
DOI: 10.1158/0008-5472.CAN-08-4205

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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