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Article

EGF receptor mutations in lung cancer: from humans to mice and maybe back to humans.

Cancer cell - 1 Jun 2006

Arteaga Carlos L

Abstract excerpt

Deletions in exon 19 and nucleotide substitutions in exon 21 are the most common mutations of the EGFR (ErbB1) in NSCLC. These mutations endow the receptor with constitutive kinase activity. Most tumors expressing these mutants respond well to EGFR tyrosine kinase inhibitors, suggesting that they are dependent on mutant EGFR signaling. Two groups developed transgenic mice in which expression of these mutants is...

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Source

Identifiers

PMID: 16766261
DOI: 10.1016/j.ccr.2006.05.014

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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