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Article

Hybrid vigor and transgenerational epigenetic effects on early mouse embryo phenotype.

Biology of reproduction - 1 Oct 2008

Han Zhiming, Mtango Namdori R, Patel Bela G, Sapienza Carmen, Latham Keith E

Abstract excerpt

Mouse embryos display a strain-dependent propensity for blastomere cytofragmentation at the two-cell stage. The maternal pronucleus exerts a predominant, transcription-dependent effect on this phenotype, with lesser effects of the ooplasm and the paternal pronucleus. A parental origin effect has been observed as an inequality in the cytofragmentation rate of embryos produced through genetic crosses of reciprocal...

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Identifiers

PMID: 18562704
DOI: 10.1095/biolreprod.108.069096
PMCID: PMC2844494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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