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Article

Adult phenotype in the mouse can be affected by epigenetic events in the early embryo.

Development (Cambridge, England) - 1 Nov 1993

Reik W, Römer I, Barton S C, Surani M A, Howlett S K, Klose J

Abstract excerpt

Major epigenetic modifications apparently occur during early development in the mouse. The factors that induce such modifications are complex and may involve the various components of a zygote. We have started to explore whether changes in the nucleocytoplasmic composition brought about by micromanipulation can induce phenotypic effects through epigenetic modifications. Nucleocytoplasmic hybrids were therefore...

Topics

Animals
DNA
Electrophoresis, Gel, Two-Dimensional
Gene Expression
Genotype
Growth
Liver
Male
Methylation
Mice
Mice, Inbred Strains
Micromanipulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nuclear Transfer Techniques

Peptides

Phenotype

Transplantation Chimera

Zygote

Source

Identifiers

PMID: 8187648
DOI: 10.1242/dev.119.3.933

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8187648-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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