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Article

Adult phenotype in the mouse can be affected by epigenetic events in the early embryo.

Development (Cambridge, England) - 1 Nov 1993

Reik W, Römer I, Barton S C, Surani M A, Howlett S K, Klose J

Abstract excerpt

Major epigenetic modifications apparently occur during early development in the mouse. The factors that induce such modifications are complex and may involve the various components of a zygote. We have started to explore whether changes in the nucleocytoplasmic composition brought about by micromanipulation can induce phenotypic effects through epigenetic modifications. Nucleocytoplasmic hybrids were therefore...

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PMID: 8187648
DOI: 10.1242/dev.119.3.933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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