Glycosylation within an antigenic site on the HN glycoprotein of Newcastle disease virus interferes with its role in the promotion of membrane fusion.

doi:10.1006/viro.1994.1506

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Article

Glycosylation within an antigenic site on the HN glycoprotein of Newcastle disease virus interferes with its role in the promotion of membrane fusion.

Virology - 1 Oct 1994

Deng R, Wang Z, Glickman R L, Iorio R M

Abstract excerpt

The binding of monoclonal antibodies to antigenic site 3 on the hemagglutinin-neuraminidase (HN) glycoprotein of Newcastle disease virus neutralizes viral infectivity and prevents syncytium formation by a mechanism other than the prevention of viral attachment. The virus can escape neutralization...

Topics

Base Sequence
Cell Line
Cells, Cultured
Epitopes
Glycosylation
HN Protein
Hemadsorption
Membrane Fusion
Molecular Sequence Data
Mutation
Newcastle disease virus
Polysaccharides
Viral Fusion Proteins

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