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Article

Generation and preliminary characterization of vertebrate-specific replication-defective Zika virus.

Virology - 2 Jan 2021

Wan Shengfeng, Cao Shengbo, Wang Xugang, Zhou Yanfei, Yan Weidong, Gu Xinbin, Wu Tzyy-Choou, Pang Xiaowu

Abstract excerpt

Zika virus (ZIKV) is a mosquito-borne flavivirus that replicates in both vertebrate and insect cells, whereas insect-specific flaviviruses (ISF) replicate only in insect cells. We sought to convert ZIKV, from a dual-tropic flavivirus, into an insect-specific virus for the eventual development of a safe ZIKV vaccine. Reverse genetics was used to introduce specific mutations into the furin cleavage motif within the...

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Identifiers

PMID: 33075709
DOI: 10.1016/j.virol.2020.09.001
PMCID: PMC7733535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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