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Article

Functional Characterization of Knockdown Resistance Mutation L1014S in the German Cockroach, Blattella germanica (Linnaeus).

Journal of agricultural and food chemistry - 15 Feb 2023

Liu Kaiyang, Ma Shuyue, Zhang Kun, Gao Ruibo, Jin Haifeng, Cao Peng, Yuchi Zhiguang, Wu Shaoying

Abstract excerpt

The effectiveness of pyrethroid insecticides is seriously threatened by knockdown resistance (kdr), which is induced in insects by inherited single-nucleotide polymorphisms in the voltage-gated sodium channel (VGSC) gene. VGSC's L1014F substitution results in the classic kdr mutation, which is found in many pest species. Other substitutions of the L1014 locus, such as L1014S, L1014C, L1014W, and L1014H, were also...

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PMID: 36701428
DOI: 10.1021/acs.jafc.2c05625

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