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Article

A single nucleotide polymorphism in the Mdm2 promoter and risk of sepsis.

American journal of surgery - 1 Jan 2009

Kleiman David A, Calvano Jacqueline E, Coyle Susette M, Macor Marie A, Calvano Steve E, Lowry Stephen F

Abstract excerpt

BACKGROUND: The Mdm2-SNP309(T/G) polymorphism has been shown to upregulate transcription of Mdm2 and subsequently attenuate the p53 pathway. Its role in regulating the human response to acute illness has not been reported. METHODS: Patients from the surgical intensive care unit were prospectively...

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Source

Identifiers

PMID: 18558393
DOI: 10.1016/j.amjsurg.2007.12.049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18558393-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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