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Article

An AC-repeat adjacent to mouse Cdkn2B allows the detection of specific allelic losses in the p15INK4b and p16INK4a tumor suppressor genes.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Mar 1998

Malumbres M, Pérez de Castro I, Santos J, Pérez-Ollé R, Fernández-Piqueras J, Pellicer A

Abstract excerpt

The cyclin-dependent kinase inhibitors p15INK4b and p16INK4a are involved in the development of a wide range of human and murine tumors. These tumor suppressor genes are inactivated by deletions frequently associated to point mutations in the coding regions or hypermethylation of their promoters. In this work, we describe a simple-sequence length polymorphism located in mouse Chromosome (Chr) 4, between the...

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Source

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PMID: 9501299
DOI: 10.1007/s003359900722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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